Results: All treatment modalities generated similar dose distributions for the subcutaneous tumor case, with the highest mean dose to the ipsilateral lung and bones in the single-field plan (0.4 and 0.4 Gy) compared to the microCT (0.1 and 0.2 Gy) and SARRP (0.1 and 0.3 Gy) plans. A 5 Gy target dose was calculated using the EGSnrc Monte Carlo codes. The authors present a comparison of treatment plans for the three modalities using two cases: a mouse with a subcutaneous tumor and a mouse with a spontaneous lung tumor. Methods: This paper presents a comparison of dose distributions generated by the three approachesâ€”a single-field irradiator with a 200â€‰kV beam and no image guidance, a small animal image-guided conformal system based on a modified microCT scanner with a 120 kV beam developed at Stanford University, and a dedicated conformal system, SARRP, using a 220 kV beam developed at Johns Hopkins University. The goal of this paper is to investigate dose distributions for three small animal radiation treatment modalities. Whereas in the past dose was delivered using a single beam and a lead shield for sparing of healthy tissue, conformal doses can be now delivered using more complex dedicated small animal radiotherapy systems with image guidance. Purpose: Small animal radiation therapy has advanced significantly in recent years.

[Department of Radiation Oncology, Molecular Imaging Program at Stanford, Stanford University, Stanford, California 94305 (United States) Modality comparison for small animal radiotherapy: A simulation studyĮnergy Technology Data Exchange (ETDEWEB)īazalova, Magdalena, E-mail: Nelson, Geoff Noll, John M.

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